Re-creating world history, Resistance: Fall of Man invites players to travel back to 1950, where an evil force called the Chimera threatens to destroy mankind. Playing as U.S. Army Ranger Nathan Hale, gamers exploring the single-player campaign are enlisted to help the U.S. and British armies defend what is left of civilized Europe. To help with this arduous task, gamers are supplied with a variety of weapons including the Auger, a lightning gun that burns through all solid objects including an enemy's cover, the Sapper, a type of weapon that shoots ooze just as flammable and volatile as napalm, and the Hedgehog, a type of grenade that shoots 50 spikes in all directions. Players may also go on a mobile assault through the game by commandeering such vehicles as the Lynx, an alien Stalker, and more.
Offline, players can team up with a friend for split-screen multiplayer action complete with the use of vehicles. Online, up to 40 gamers can get together for such events as "Deathmatch," "Meltdown," and "Breach." In "Breach," players must take out the opposition's reactor while simultaneously taking control of five "nodes" located throughout the map. "Meltdown" is a simplified version where gamers focus on controlling the five "nodes," and unlike "Breach," the size of the map and number of players may be customized. Each "node" supplies gamers with a bonus, such as better radar or more weapons at the home base. Due to the large number of players per game, vehicles are not included in online multiplayer action.